1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Orexin Receptor (OX Receptor) Isoform

Orexin Receptor (OX Receptor)

 

Orexin Receptor (OX Receptor) Related Products (29):

Cat. No. Product Name Effect Purity
  • HY-133898
    Danavorexton
    Activator 98.36%
    Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms.
  • HY-P1339A
    Orexin B, human TFA
    Agonist 99.16%
    Orexin B, human (TFA) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
  • HY-15653
    Filorexant
    Antagonist 99.27%
    Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding).
  • HY-P99945
    Revdofilimab
    Activator 99.35%
    Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells.
  • HY-P99836
    Cudarolimab
    Inhibitor
    Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research.
  • HY-168571
    BTF
    BTF shows a selective binding affinity for OX1R with the Ki values of 2.33 nM and 62.8 nM of OX1R and OX2R, respectively.
  • HY-159835
    Oveporexton
    Agonist
    Oveporexton is an orexin type 2 receptor (OX2R) agonist.
  • HY-137452A
    (R,R)-Suntinorexton
    Agonist 99.13%
    (R,R)-Suntinorexton is a isomeride of Suntinorexton (HY-137452). Suntinorexton is a orexin type 2 receptor agonist.
  • HY-10806
    SB-649868
    Antagonist 99.87%
    SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
  • HY-136181A
    YNT-185
    Agonist 98.36%
    YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.
  • HY-147294
    Nivasorexant
    Antagonist 99.74%
    Nivasorexant is a potent orexin receptor antagonist.
  • HY-137440A
    Firazorexton hydrate
    99.94%
    Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). Firazorexton hydrate inhibits fragmentation of wakefulness and cataplexy-like episodes in mouse models of narcolepsy.
  • HY-12301
    MK-3697
    Antagonist 98.83%
    MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.
  • HY-P1349
    Orexin B, rat, mouse
    Agonist
    Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
  • HY-P1349A
    Orexin B, rat, mouse TFA
    Agonist
    Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.
  • HY-152843
    Fazamorexant
    Antagonist 99.73%
    Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research.
  • HY-136922
    Orexin receptor antagonist 2
    Antagonist 98.04%
    Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia.
  • HY-P99911
    Efizonerimod alfa
    Activator 98.57%
    Efizonerimod alfa is a potent monoclonal antibody OX40 activator. Efizonerimod alfa can be used for cancer research.
  • HY-137093
    Orexin receptor antagonist 3
    Antagonist 99.62%
    Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist, which is extracted from the patent WO2011050198A1.
  • HY-13796
    IPSU
    Antagonist 98.10%
    IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.